The relationship of plasma prothrombin concentration and the degradation rate of serum "prothrombin-converting factor" during dicumarol therapy.
نویسندگان
چکیده
on fibrinogen and oxalated plasma revealed that serum obtained from recently coagulated whole blood contains a factor which causes conversion of prothrombin to thrombin.” 2 Since fibrinogen could not be converted to fibrin in any significant degree by addition of fresh serum, and since the rapidity of coagulation of oxalated plasma by the serum factor was proportional to the prothrombin concentration of the plasma, it was assumed that fresh human serum contained a ‘prothrombin-converting factor.” In addition, it was shown that the
منابع مشابه
THE RELATIONSHIP OF PLASMA PROTHROMBIN CONCENTRATiON AND THE DEGRADATION RATE OF SERUM “PROTHROMBIN- CONVERTING FACTOR” DURING DICUMAROL THERAPY
on fibrinogen and oxalated plasma revealed that serum obtained from recently coagulated whole blood contains a factor which causes conversion of prothrombin to thrombin.” 2 Since fibrinogen could not be converted to fibrin in any significant degree by addition of fresh serum, and since the rapidity of coagulation of oxalated plasma by the serum factor was proportional to the prothrombin concent...
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Normal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. Inherited alteration of factor V and prothrombin gene, the G20210A mutation, increases the resistance of factor V to degradation and booster production of prothrombin respectively. These alterations can increase hypercoagulability leading to thrombotic consequences. We aimed to assess the frequencies of ...
متن کاملStandardization of the Quick Prothrombin Test with Reference to the Statistical Significance of Variations in the Prothrombin Concentration with Use of a Stable Thromboplastin
W ITH increasing use of tests of the prothrombin concentration as an aid in the diagnosis of diseases of the liver and as a guide in vitamin K and dicumarol therapy,’6 it is imperative that the determinations be accurate. There are many ways of measuring the prothrombin concentration and each admits of numerous sources of error. Even when the most careful technic is practiced, appreciable error...
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عنوان ژورنال:
- Blood
دوره 5 4 شماره
صفحات -
تاریخ انتشار 1950